Effects of Thermal Curing Conditions on Drug Release from Polyvinyl Acetate–Polyvinyl Pyrrolidone Matrices

Effect of Formulation Variables on Phenobarbital Release from HPMC Matrices

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...

Effect of Polyvinyl Pyrrolidone and Ethyl Cellulose Concentration on Release Profile and Kinetics of Glibenclamide Extended Release Dosage Form System

The aim of present work was to optimize the effect of Ethyl Cellulose (EC) and Polyvinyl Pyrrolidone (PVP) concentration in extended release solid dispersion of Glibenclamide using combination of hydrophilic and hydrophobic polymers such as Polyvinyl Pyrrolidone and Ethyl cellulose. The advantage of solid dispersion technique provides a unique approach to particle size reduction and increased r...

Modeling of drug release from collagen matrices.

Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehydrothermally crosslinked. Assuming Fickian diffusion a one-dimensional model was developed and te...

Modulation of drug release from hydrophilic matrices

Polyvinyl pyrrolidone (PVP) in cataract surgery.

Early reformation of the anterior chamber after intraocular surgery is of paramount importance, its absence or delay leading to peripheral anterior synechiae and aphakic glaucoma (Troncoso, 1933; Kronfeld and Grossman, 1941; McLean, I94I; Meyer and Sternberg, 1950). Selinger (1937) injected air after cataract operations to restore the normal curvature of the cornea. He concluded that air preven...